妮可F. Diette, Ph值.D.
Assistant Professor of Biology and Program Director of Allied Health Degrees
Biological and Physical Sciences and Mathematics | Turock School of Arts and Sciences
关于
I first knew I wanted to study science when I met an inspirational teacher in middle school. He had such a talent for helping young minds understand scientific concepts while making the subject incredibly fun.
完成博士学位后.D. in 2016, I moved to Denver, Colorado where I began a post-doctoral fellowship at the Charles C. Gates Center for Regenerative Medicine and the University of Colorado, Anschutz Medical 校园 in the lab of Dr.’s Anya Bilousova and Igor Kogut. Among other projects, I worked toward developing a novel animal model for Ehlers-Danlos Syndrome. Eventually earning the title of 研究 Associate, I enjoyed the research greatly – however, I missed being in the classroom.
I moved back home to Northeastern PA to begin my role as an Assistant Professor of Biology at 重点大学 in the fall of 2021. 在这里, I have enjoyed being able to apply both my scientific knowledge as well as research experience to create a well-rounded education and fun environment for students.
教育-学位 & 认证
- Ph.D., M.S., & B.S.生物学- St. 约翰的大学
“I love 重点大学 because it’s a place where you feel like you count. Professors and students get to know and care about one another. That kind of personal attention to one’s education is unmatched by other institutions.”
妮可·迪特博士.D.
- 普通生物学I
- 细胞生物学
- 生物伦理学
- 营养
- 遗传学
- 免疫学
- 生理学
Millions of Americans are personally affected by cancer, the second-most leading cause of death. Cancer is a nondiscriminatory disease and nearly forty percent of men and women will be diagnosed with cancer at some point in their lifetime. RNA聚合酶III, which transcribes a number of untranslated RNAs responsible for regulating cell growth, is deregulated in a variety of cancers. EGCG (found in green tea) can negatively regulate RNA pol III, possibly revealing novel mechanisms responsible for the anti-cancer properties of the natural product. 最近, I have become interested human telomerase (hTERT), and the delicate balance between rejuvenation and immortalization. 此外, in addition to regulating RNA pol III activity, studies suggest that EGCG can modulate hTERT activity via the induction of epigenetic changes. 必然地, I have become quite interested in natural occurring products and the effects they may or may not have on cancers. 源于自然, these bioactive products have gained much popularity in recent times, allowing the tremendous expansions of the natural supplement industry. My research interest lies in investigating different natural products such as resveratrol (found in red wine), 姜黄素(姜黄), and quercetin (found in fruits, 蔬菜, tea and grains) to name a few, and how they may affect cancer, with particular interest in the regulation of hTERT and status of telomeres.
- Assistant Professor of Biology, 重点大学, August 2021-Present
- 研究助理查尔斯C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical 校园 2020-2021
- NIH T32 Postdoctoral 研究 Fellow, Charles C. Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical 校园 2016-2019
- Adjunct Lecturer, Department of Science, Borough of Manhattan Community College 2012
- N.Diette, Kogut I, Bilousova G. Generation of a Full-Thickness Human Skin Equivalent on Immunodeficient Mouse. 方法: 2019年5月21日.
- 麦格拉思,P. S., Diette N.， Kogut, I.比卢索娃，G. RNA-Based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells. 力. 经验值. 2018年11月26日.
- Ricigliano VA, Sica VP, Knowles SL, Diette N， Howarth DG, Oberlies NH. Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots. 植物化学, 2020.
- Diette N, Koo J, Cabarcas-Petroski S, 施拉姆 L. Gender Specific Differences in RNA Polymerase III Transcription. J致癌诱变剂, 2016.
- 古永锵J., S. Cabarcas-Petroski J.L. 皮特里, Diette, R.J. 白色和L. 施拉姆.Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein. BMC癌症, 2015.